Sertindole

Q: What is the Sertindole?

Sertindole is off-white to Pale yellow solid, while it's Molecular Formula is C24H26ClFN4O. off-white to Pale yellow solid antipsychotic;Dopamine D2/Serotonin 5-HT2 receptor antagonist

Quality products?make an important contribution to long-term revenue and profitability. Manufacturer supply high quality Sertindole 106516-24-9 with GMP standards

1.What is the Sertindole ?

antipsychotic;Dopamine D2/Serotonin 5-HT2 receptor antagonist

: 2387-20-4
1-(2-chloroethyl)imidazolidin-2-one

: 138900-27-3
5-chloro-1-(4-fluorophenyl)-3-(4-piperidinyl)-1H-indole

: 106516-24-9
Sertindole

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide; In various solvent(s); for 16h; Heating;	87%

: 41979-39-9
4-piperidone hydrochloride

: 106516-24-9
Sertindole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: TFA, AcOH / 0.5 h / Heating 2: H₂, AcOH / PtO₂ / ethanol / 16 h / 1900 - 2280 Torr 3: 87 percent / K₂CO₃, KI / various solvent(s) / 16 h / Heating With hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; platinum(IV) oxide; In ethanol;

2.What is the CAS number for Sertindole ?

The CAS number of Sertindole is 106516-24-9.

More information of Sertindole 106516-24-9 are:

CAS?Number	106516-24-9
Density	1.367 g/cm³
Melting Point	95-100 °C
Boiling Point	592.065 °C at 760 mmHg
Flash Point	311.87 °C
Vapor Pressure	5.44E-14mmHg at 25°C
Refractive Index	1.67
PSA	40.51000
LogP	4.83220
Pka	14.53±0.20(Predicted)

3.What are another words for Sertindole ?

Synonyms?for?Sertindole 106516-24-9:Serdolect;Zerdol;

4.What is the molecular formula of Sertindole?

The chemical formula of ?Sertindole is?C24H26ClFN4O which containing 24 Carbon atoms,26 Hydrogen atoms,1 Chlorine atoms,1 Fluorine atoms,4 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of??Sertindole?is 440.948.

5.What is Sertindole (106516-24-9) used for?

Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively). It also binds to histamine H1 and α1- and α2-adrenergic receptors (Kds = 320, 3.9, and 190 nM, respectively). In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats. Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats. It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice. Sertindole (0.02-0.32 mg/kg) also prevents accuracy deficits and anticipatory over-responding in the 5-choice serial reaction time task (5CSRTT) induced by the NMDA receptor antagonist (R)-CPP in rats. Formulations containing sertindole have been used in the treatment of schizophrenia.

InChI:InChI=1/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)

Relevant articles related to Sertindole:

Article

Source

Process for the preparation of 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole and method of manufacturing sertindole

Example 8, (2010/01/31)

6.Buy Sertindole with the best price .

Nanjing qiangxin chemical Co., LTD. is a quality supplier of Sertindole. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Sertindole 106516-24-9.