2-Chloro-5-hydroxymethylpyridine
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- Molecular Formula: C6H6ClNO
- Molecular Weight: 143.573
- Appearance/Colour: white crystalline powder
- Vapor Pressure: 0.00227mmHg at 25°C
- Melting Point: 51-54 °C(lit.)
- Refractive Index: 1.572
- Boiling Point: 276.7 °C at 760 mmHg
- PKA: 13.32±0.10(Predicted)
- Flash Point: 121.2 °C
- PSA： 33.12000
- Density: 1.324 g/cm3
- LogP: 1.22730
2-Chloro-5-hydroxymethylpyridine(Cas 21543-49-7) Usage
InChI:InChI=1/C6H6ClNO/c7-6-2-1-5(4-9)3-8-6/h1-3,9H,4H2
21543-49-7 Relevant articles
Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594
Zhang, Chuan-Xin,Ge, Ze-Mei,Cheng, Tie-Ming,Li, Run-Tao
, p. 2013 - 2016 (2006)
A series of highly sterically hindered s...
-
Ziegler,Sweeny
, p. 1097 (1969)
-
Ultrasounds-mediated 10-seconds synthesis of chalcones as potential farnesyltransferase inhibitors
Farce, Amaury,Ghinet, Alina,Homerin, Germain,Nica, Adrian Sorin,Dubois, Jo?lle
supporting information, (2020/04/10)
A broad range of chalcones and derivativ...
New-type compound and preparation method and application thereof
-
Paragraph 0043-0046; 0050, (2019/05/02)
The invention relates to a new-type comp...
MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
-
Page/Page column 40, (2018/03/25)
The present invention relates to compoun...
INHIBITORS OF HEPATITIS C VIRUS POLYMERASE
-
Paragraph 578; 581, (2016/10/11)
The present invention provides, among ot...
21543-49-7 Process route
-
-
23100-12-1
6-chloronicotinylaldehyde
-
-
5326-23-8
6-Chloro-3-pyridinecarboxylic acid
-
-
21543-49-7
2-Chloro-5-hydroxymethylpyridine
| Conditions | Yield |
|---|---|
|
With
lithium hydroxide;
In
ethanol; water;
at 21 - 32 ℃;
for 0.00555556h;
Sonication;
|
41.3%
43.6% |
-
-
73781-91-6
6-Chloronicotinic acid methyl ester
-
-
21543-49-7
2-Chloro-5-hydroxymethylpyridine
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
|
100%
|
|
6-Chloronicotinic acid methyl ester;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
With
sodium hydroxide;
In
tetrahydrofuran;
|
96%
|
|
6-Chloronicotinic acid methyl ester;
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at -78 - 20 ℃;
for 1h;
With
rochelle salt;
In
tetrahydrofuran; dichloromethane; water; toluene;
|
95%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
|
88%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
|
88%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
|
70%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
|
70%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
|
44%
|
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 1h;
|
|
|
With
sodium sulfate;
In
tetrahydrofuran;
|
21543-49-7 Upstream products
-
5326-23-8
6-Chloro-3-pyridinecarboxylic acid
-
6311-35-9
6-bromonicotinic acid
-
85320-79-2
5-chloro-nicotinoyl chloride
-
58757-38-3
6-Chloronicotinoyl chloride
21543-49-7 Downstream products
-
82674-16-6
2-chloro-5-chloromethylpyridine chydrochloride
-
101990-45-8
2-bromo-5-bromomethylpyridine
-
70258-18-3
2-chloro-5-(chloromethyl)pyridine
-
915715-38-7
5-[(benzyloxy)methyl]-2-chloropyridine
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